FORMULATIONS FOR SKIN TREATMENT CONTAINING CARBOXYLIC ACID SUBSTITUTED IDEBENONE DERIVATIVES, AS WELL AS METHODS FOR PREPARING AND USING THEM Russian patent published in 2014 - IPC A61K8/37 A61Q19/00 A61Q19/02 A61Q19/06 A61Q19/08 C07C69/675 A61K31/23 A61P17/02 A61P17/16 A61Q17/04 C07C67/08 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new idebenone derivatives substituted by carboxylic acid with general formula I wherein R¹ represents C₂-C₂₂ saccharic acid with a direct or branched chain, while two or more hydroxy groups are independently substituted by C₁-C₂₂ carboxylic acid, wherein the term 'branched' refers to one or more groups of a lower alkyl. The invention also refers to a formulation for skin treatment containing the above idebenone derivatives, a method of treating the skin changes by local applications with these idebenone derivatives, as well as to methods of synthesis thereof. When adding the idebenone derivatives according to the present invention into the formulations for local application, they possess the antioxidant action effective in treating the skin changes.

EFFECT: above idebenone derivatives have unexpectedly occurred to be effective in skin treatment, especially in relation to skin tolerance.

20 cl, 1 tbl, 5 ex