FIELD: pharmacology.
SUBSTANCE: invention relates to a therapeutical or preventive agent for treatment of hypertension or high blood pressure and to the appropriate method of treatment with its usage. The proposed agent contains (a) and (b) as active ingredients: (a) 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolcarbonic acid (febuxostat) or its pharmaceutically acceptable salt; (b) a compound selected from a group made of blockers of calcium channels, blockers of a receptor of angiotensin II, and inhibitors of an angiotensin-converting ferment and their salts applicable from the point of view of medicine.
EFFECT: synergism of lower blood pressure on a model of spontaneous hypertension.
9 cl, 4 tbl
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| COMBINATION OF DIPEPTIDILPEPTIDASE IV (DPP IV) INHIBITOR AND CARDIOVASCULAR SUBSTANCE | 2003 |
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| APPLICATION OF ORGANIC COMPOUNDS | 2005 |
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| COMPOSITION CONTAINING FIXED DOSE OF ANGIOTENSIN-TRANSFORMING ENZYME AND CALCIUM CANAL ANTAGONIST AND METHOD FOR PRODUCING THE COMPOSITION AND TREATING CARDIOVASCULAR DISEASES | 1998 |
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| HYPOTENSIVE COMBINATION OF VALSARTAN AND CALCIUM CANAL BLOCKERS | 1999 |
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| HYPOTENSIVE COMBINATION OF VALSARTAN AND CALCIUM CHANNEL BLOCKING AGENT | 1999 |
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RU2243768C2 |
