FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to pharmaceutical coformulated preparative forms containing calcium channel blocker on the basis of dihydropyridine, such as amlodipine and ARB (angiotensin-2 receptor blocker), such as losartan.
EFFECT: group of inventions refers to chronotherapeutic coformulated preparative forms for preventing and treating cardiovascular diseases on the basis of xenobiotics and chronotherapy for providing chronotherapeutic release of two therapeutic agents hereby enhancing therapeutic activity as compared with the combined introduction of each therapeutic agent in the form of an individual pill, simultaneously reducing side effects and maintaining such high therapeutic activity as possible for a certain period of time a day when a risk of cardiovascular complications is highest.
20 cl, 11 dwg, 7 tbl, 30 ex
