TECHNETIUM AND RHENIUM COMPLEXES WITH BIS(HETEROARYLS) AND METHODS FOR USING THEM Russian patent published in 2015 - IPC C07D213/38 C07D233/64 C07D403/12 C07F13/00 A61K51/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound presented by formula OR or its pharmaceutically acceptable salt or solvate. The radical values are as follows: R^t - H, C₁-C₈ alkyl group, ammonium ion, alkali or alkali-earth ion; R₈₄ - substituted C_1-8 alkyl; R - C_1-8 hydroxyalkyl, C_1-8 alkoxyalkyl, C_1-8 aminoalkyl, (CH₂)₈(NHC(S)NH)Ph(SO₂NH₂), (CH₂)_dPh(SO₂NH₂), (CH₂)₅C(O)NH-(1-acetylpyrrolidin-2-yl)boric acid, (1-acetylpyrrolidin-2-yl)boric acid, (CH₂)₄CH(NH₂)CO₂H, (CH₂)₃CH(NH₂)CO₂H, (CH₂)₂CH(NH₂)CO₂H, -(CH₂)_d-R₈₀, -C(O)(CH₂)_d-R₈₀, or amino acid radical; R₈₀ is carboxylate, C_6-10 aryl, 3-6-merous heterocyclyl, amino acid; d represents an integer within 0 to 12 inclusively; and R₈₂, R₈₃, R₈₅ and R₈₆ are hydrogen, substituted or unsubstituted alkyl, ether, ester, CH₂CH₂OCH₂CH₃, CH₂CH(OCH₃)₂, -(CH₂)_d-R₈₀, or (CH₂)_dR₈₇; wherein R₈₇ represents phosphonate or phosphorinate. What is also presented is a complex containing the above compound and a radionuclide.

EFFECT: compound can be used as diagnostic or therapeutic agents.

11 cl, 13 dwg, 10 tbl, 23 ex