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(19)

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2 532 912

(13)

(51)

IPC

C07C275/24(2006-01-01)

C07D213/56(2006-01-01)

C07D403/12(2006-01-01)

C07D401/12(2006-01-01)

C07F13/00(2006-01-01)

A61K49/00(2006-01-01)

A61K51/04(2006-01-01)

(21) (22)

Application

2011127468/04, 2009-12-04

(24)

Start date

2009-12-04

(22)

Actual filing date

2009-12-04

(45)

Published

2014-11-20

(72)

Inventor

Babich Dzhon U.Tsimmerman. KrejgDzhojal DzhonMareska Kevin P.Lu GenliangKhil'Er Shon

(73)

Holder

Molik'Jular Insajt Farmas'Jutikalz, Ink.

TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS FOR USING THEM FOR PSMA INHIBITION Russian patent published in 2014 - IPC C07C275/24 C07D213/56 C07D403/12 C07D401/12 C07F13/00 A61K49/00 A61K51/04

Abstract RU 2532912 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new radiopharmaceutical compounds of structural formula

In formula I, R means H or a (C₁-C₈)alkyl group; W means a bond, -CH(NH₂)-, -C(O)-NH-CH(COOH)-, -O-(CH₂)_n-O-(CH₂)_n- or -(CH₂)_nO(CH₂)_nO(CH₂)_n; Z means -NHC(O)-, -NH-C(O)-CH(NH₂)- or -C(O)-NH-CH(COOH)-; e is an integer from 1 to 4; f is an integer from 0 to 10; g is an integer from 0 to 10; n is an integer from 0 to 2; the radical NR^aR^b values are presented in the patent claim.

EFFECT: invention refers to the radionuclide complex containing a radioactive metal and the above compounds, to a pharmaceutical compound for visualising and to a method for visualising any patient's region, e.g. a tissue specified in the spleen tissue, kidney tissue or PSMA-expressing tumour tissue.

21 cl, 6 dwg, 1 tbl, 18 ex

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RU 2 532 912 C2

Authors

Babich Dzhon U.

Tsimmerman. Krejg

Dzhojal Dzhon

Mareska Kevin P.

Lu Genliang

Khil'Er Shon

Dates

2014-11-20—Published

2009-12-04—Filed