FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a method for preparing a compound of formula
,
wherein R represents one or more groups optionally specified in halogen atoms, and n makes 1 or 2; or its pharmaceutically acceptable salts. The method involves the following stages: (1) reacting a compound of formula
,
wherein X' is specified in chlorine, bromine, iodine and triflate group (CF3SO3), with 1,2-dibromethane to form a compound of formula
,
(2) binding in the presence of a palladium catalyst representing mixture of Pd(OAc)2 and triphenylphosphine, a compound of formula (V) to a compound of formula 
,
wherein R is such as specified above to form a compound of formula 
;
(3) hydrolysing the compound of formula (VII) to form a compound of formula (IA). The invention also refers to a method for preparing a pharmaceutical composition involving the above stages (1)-(3) and the additional stage involving mixing to one or more pharmaceutically acceptable excipients.
EFFECT: method enables preparing the high-yield products.
9 cl, 5 ex
