FIELD: biotechnology.
SUBSTANCE: method includes the step of formula VII compound reaction with the formula X vompound in an organic solvent in the presence of organic amine and amide coupling agent. In formulas:
, 
and 
Ar represents phenyl, the said phenyl can be unsubstituted or substituted 1-3 times with substituents independently selected from the group consisting of: halogen, C1-6alkyl, C1-6alkoxy and haloC1-6alkyl; R2 and R3 are each independently selected from the group consisting of: hydrogen, C1-6alkyl, haloC1-6alkyl, C1-6alkoxy and hydroxyC1-6alkyl; and Ar' represents the pyridine group: 
, where R4 is selected from the group consisting of hydrogen, halogen, C1-6alkyl, C1-6alkoxy and (C1-6alkoxy)C1-6alkyl; R5 is selected from the group consisting of hydrogen, halogen, C1-6alkyl and haloC1-6alkyl; R6 is selected from the group consisting of hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, C1-6alkoxy, (C1-6alkoxy)C1-6alkyl and cyano.
EFFECT: invention is an effective antagonist of orexin receptors, and may be useful for treatment of sleep disorders such as insomnia.
30 cl, 8 ex
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