FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing benzoaza-12-crown-4, which is carried out via condensation of o-aminophenol with triethylene glycol dichloride, followed by separation of the end product, the method being characterised by that the initial o-aminophenol in a medium of isopropyl alcohol is treated with sodium hydroxide and held at 60-80°C for 60-80 minutes, followed by addition of a stoichiometric amount of triethylene glycol dichloride and stirring the obtained reaction mass while boiling for 16-20 hours, followed by cooling, acidification with hydrochloric acid to pH=3-4, filtering, leaching the filtrate with aqueous ammonium hydroxide solution to pH=8-9 and separating the end product by evaporation and vacuum distillation.
EFFECT: obtaining benzoaza-12-crown-4 of high quality with high output.
4 cl, 2 tbl, 3 ex
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