FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing benzoxazole derivatives of formula 1 ,
where X is a single bond -СН=СН-; ; ; -СН2-СН2-; -СН2-; -СН2-NH-СН2-СН2-; CH2-O-CH2-CH2-. The method is realised by reacting corresponding nitriles (given in claim 1) with ortho-aminophenol hydrochloride in a sealed glass tube. The process is carried out at molar ratio of nitrile to ortho-aminophenol hydrochloride of 1:1.2 and at temperature of 180-190°C.
EFFECT: improved method of producing benzoxazole derivatives.
2 cl, 8 ex
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Authors
Dates
2013-01-27—Published
2011-03-14—Filed