METHOD FOR FENBENDAZOLE ENCAPSULATION Russian patent published in 2015 - IPC A61K9/50 A61K31/41 A61K47/26 A61J3/07 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to drug microencapsulation, particularly to a method for preparing fenbendazole microcapsules. The method is characterised by the fact that a microcapsule coating is presented by carboxymethyl cellulose; fenbendazole dissolved in dioxane, or dimethylformamide, or dimethylsulphoxide is dispersed into a solution of carboxymethyl cellulose in acetone in the presence of surfactant E472c at 1000 rpm; fenbendazole and sodium carboxymethyl cellulose are taken in weight ratio 1:3; carbinol and distilled water taken in volumetric ratio 2:1 are added; the produced suspension of microcapsules is filtered and dried; the process of fenbendazole microencapsulation is performed at 25°C.

EFFECT: method provides simplifying and accelerating the process of fenbendazole microcapsules in carboxymethyl cellulose, reducing the loss accompanying the process of microcapsules (higher weight yield).

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