METHOD OF FENBENDAZOLE ENCAPSULATION Russian patent published in 2015 - IPC A61K9/50 A61K31/417 A61K47/30 A61J3/07 

Abstract RU 2543337 C2

FIELD: chemistry.

SUBSTANCE: sodium carboxymethylcellulose is used as coating for microcapsules. Charge of fenbendazole, dissolved in dioxane, or dimethylsulphoxide, or dimethylformamide, is dispersed into solution of sodium carboxymethylcellulose in cyclohexanol in presence of surface-active substance E472c, mixing is performed at 1000 rev/s. Weight ratio of fenbendazole and sodium carboxymethylcellulose constitutes 1:3 respectively, after which mixture of butanol and distilled water taken in volume ratio 2:1 respectively is added, obtained suspension of microcapsules is filtered and dried. The process of obtaining fenbendazole microcapsules is realised at 25°C.

EFFECT: simplification and acceleration of the process of obtaining fenbendazole microcapsules in carboxymethylcellulose, reduction of loss in the process of obtaining microcapsules.

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RU 2 543 337 C2

Authors

Bykovskaja Ekaterina Evgen'Evna

Krolevets Aleksandr Aleksandrovich

Dates

2015-02-27Published

2013-05-29Filed