PYRAZINES APPLICABLE AS DELTA-OPIOID RECEPTOR MODULATORS Russian patent published in 2015 - IPC C07D401/14 C07D403/14 C07D401/04 C07D403/12 C07D405/14 A61K31/497 A61K31/506 A61K31/4427 A61K31/4025 A61P25/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry, namely to pyrazine derivatives of formula I, as well as to their enanthiomers, diastereomers and pharmaceutically acceptable salts, wherein R₁ is specified in a group consisting of ii) pyridinyl optionally having one substitute specified in a group consisting of C_1-4alkoxy and cyano; and iii) pyrimidin-5-yl; or R₁ optionally represents methoxymethyl, when Y represents ethinyl; Y represents ethinyl or a bond; R₂ represents phenyl, benzofuranyl, 2,3-dihydrobenzofuranyl, benzo[1,3]dioxol-5-yl, indolyl or pyridinyl substituted by methyl, phenyl has one to two substitutes independently specified in a group consisting of C_1-4alkyl, C_1-4alkoxy, fluorine, chlorine, cyano, cyanomethyl, difluoromethyl, trifluoromethyl and hydroxy; or R₂ represents phenyl having one C_1-4alkylcarbonylamino or 1H-imidazol-1-yl substitute; X represents O or CH₂; L is absent, and R₃ represents 4-aminocyclohexyl, or L represents methylene, while R₃ is specified in a group consisting of i) pyrrolidin-2-yl; ii) 1-aminoeth-1-yl; and iii) 1-aminocyclopent-1-yl; or R₃ is combined into one cycle with L nitrogen atom to which L is attached to form piperazinyl. Besides, the invention refers to specific compounds, a pharmaceutical compound based on a compound of formula I, a method of treating pain and some neurodegenerative diseases.

EFFECT: there are produced new pyrazine derivative effective in treating pain and some neurodegenerative diseases.

21 cl, 3 tbl, 13 ex