FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely to surgery and diagnostic research methods, in particular to intraoperative visualisation. The targeted delivery of conjugates of nano-sized anti-Stokes phosphori (NAP) with molecules, selectively binding with a target biostructure, subjected to visualisation is carried out. Irradiation of a pathological focus by infra-red radiation in the range of 975-980 nm is carried out. Intraoperative visualisation of the luminescence of the surface and subsurface pathological foci is performed in the blue spectral range by the naked eye. Deep optic probing by means of an optic probe is performed to register the pathological foci, located at the depth, mainly, in the infra-red spectral range.
EFFECT: method provides high sensitivity of the differentiation of the pathological foci from normal tissues, high resolution of visualisation, makes it possible to differentiate the surface and subsurface pathological foci by the naked eye, and the pathological foci, located at the depth, by means of the optic probe.
4 cl, 3 ex, 7 dwg
