METHOD OF PRODUCING FUNCTIONALISED IMAGING AGENTS WITH ANTI-STOKES PHOTOLUMINESCENCE BASED ON POLYACROLEIN DISPERSIONS Russian patent published in 2017 - IPC A61K49/12 B82B1/00 B01J13/00 

FIELD: chemistry.

SUBSTANCE: invention relates to chemistry of high-molecular compounds and a method of producing imaging agents with anti-Stokes photoluminescence in form of an aqueous dispersion of polyacrolein particles, containing nano-sized anti-Stokes phosphors, by polymerisation of acrolein in aqueous alkaline medium, carried out in two steps, first of which comprises settling polymerisation, and at second step obtained product undergoes further radical polymerisation in presence of a water-soluble initiator K₂S₂O₈, characterised by that first polymerisation step is carried out i presence of anti-Stokes phosphors in amount of 0.1–1.5 wt% with respect to monomer, pre-treated with tetramethylammonium hydroxide, which are used as a polymerisation initiator.

EFFECT: invention makes it possible to encapsulate nanosized anti-Stokes phosphors in volume of polymer matrix, which protects optical properties of nanophosphors from biological media and provides colloid-chemical properties required for use as imaging agents in biological analysis and biological imaging.

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