METHOD OF PRODUCING CALCIUM SALTS OF OPTICALLY ACTIVE [D] OR RACEMIC [D, L] HOMOPANTOTHENIC ACID Russian patent published in 2015 - IPC C07C235/12 C07C231/04 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a calcium salt of optically active D-homopantothenic acid, used as a medicinal agent with nootropic action. The method includes treating γ-aminobutyric acid with calcium compounds in a solvent medium, followed by condensation of the calcium salt of γ-aminobutyric acid with pantolactone. Treatment of γ-aminobutyric acid is carried out with calcium metal in a medium of dehydrated isopropanol. Condensation of the calcium salt of γ-aminobutyric acid with D-(-)-pantolactone is first carried out in a medium of dehydrated isopropanol with simultaneous distillation thereof, and then after complete distillation - in a melt at temperature of 103-105°C for two hours. Aqueous isopropanol is added to the melt and the mixture is stirred. The end product is separated from aqueous isopropanol by filtering and dried at 80-90°C. The invention also relates to a method of producing a calcium salt of racemic D,L-homopantothenic acid.

EFFECT: disclosed methods increase the output of the end product, cut the overall duration of the process and consumption of dehydrated isopropanol.

2 cl, 2 ex