FIELD: calcium D-homopantothenoate and pharmaceutical composition containing the same.
SUBSTANCE: calcium D-homopantothenoate is obtained by treatment of γ-aminobutiric acid with calcium compound (e.g. calcium isopropilate) followed by heating and condensation of calcium γ-aminobutirate with D-(-)-pantolactone in presence of solvent (e.g. isopropanol). Calcium isopropilate is obtained by dissolution of metal calcium in isopropanol at elevated temperature. Target product is separated by crystallization from isopropanol followed by recrystallization from aqueous solution of isopropanol with water content of 0-20 wt %. Pharmaceutical composition containing claimed salt has nootropic action and is especially effective for treatment of infant mental retardation.
EFFECT: simple and short step process with high yield.
3 ex
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