FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to fluorinated aminotriazole derivatives of formula
,
wherein A represents a group specified in furanyl, oxazolyl and thiazolyl, wherein two attachment points of the above group are found in 1,3-position; R1 represents phenyl, which is unsubstituted, mono- or disubstituted, wherein the substitutes are independently specified in a group consisting of halogen, methyl, methoxy group, trifluoromethyl, trifluormethoxy group and dimethylamino group; and R2 represents hydrogen, methyl, ethyl or cyclopropyl. Besides, the invention refers to a pharmaceutical composition containing the compound of formula (I), and to using the compound of formula (I) for preparing a therapeutic agent.
EFFECT: compounds of formula (I) possessing the agonist activity in relation to ALX receptor.
26 cl, 2 tbl, 36 ex
| Title | Year | Author | Number |
|---|---|---|---|
| OXAZOLYL-METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS | 2011 |
|
RU2588567C2 |
| AMINOPYRAZINE COMPOUNDS WITH THE A2A ANTAGONIST PROPERTIES | 2015 |
|
RU2727805C2 |
| AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | 2008 |
|
RU2492167C2 |
| BRIDGED SPIRO[2,4]HEPTANE DERIVATIVES AS ALX AND/OR FPRL2 RECEPTOR AGONISTS | 2010 |
|
RU2540274C2 |
| TRIAZOLO-PYRIMIDINE COMPOUNDS AND THEIR USE | 2019 |
|
RU2802866C2 |
| DERIVATIVES OF N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDES AND THEREOF APPLICATION AS PDE10A INHIBITORS | 2011 |
|
RU2562066C2 |
| 2-AZA-BICYCLO[3,3,0]OCTANE DERIVATIVES | 2008 |
|
RU2478099C2 |
| DERIVATIVES OF DIHYDROBENZO[b][1,4]DIAZEPINE-2-ONE AS I mGluR2 ANTAGONISTS | 2002 |
|
RU2270197C2 |
| DERIVATIVES OF BENZIMIDAZOL INHIBITING FACTOR Xa | 2004 |
|
RU2346944C2 |
| 1-[M-CARBOXAMIDO(HETERO)ARYL-METHYL]-HETEROCYCLYL-CARBOXAMIDE DERIVATIVES | 2013 |
|
RU2644761C2 |
