FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to compound of formula (I) or its pharmaceutically acceptable salt thereof, in which R1 denotes phenyl, which is unsubstituted or mono-substituted halogen, (C1-C4)alkyl, (C1-C4)alkoxy group, (C1-C2)fluoroalkyl or (C1-C2)fluoralkoxygroup; R2 denotes hydrogen, methyl or cyclopropyl; R3 and R4 are identical and mean hydrogen or methyl; and R5 denotes (C1-C2)alkyl. Invention also relates to pharmaceutical composition having ALX receptor agonist activity and containing as active substance compound of formula (I) or its pharmaceutically acceptable salt in pharmaceutically active amount and at least one therapeutically inert filler. Compound of formula (I) or its pharmaceutically acceptable salt thereof are used for preventing or treating disease selected from rheumatoid arthritis, acute pulmonary injury, asthma, cystic fibrosis, inflammatory bowel disease, dry keratoconjunctivitis, sepsis, retroviral infections mediated HIV, cardiovascular disorders, atopic dermatitis, pulmonary fibrosis and Alzheimer's disease.
EFFECT: oxasolilmethyl ester derivatives of formula (I) for use as medicinal agent for preventing or treating disease responding to ALX receptor activation.
18 cl, 4 tbl, 15 ex
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