FIELD: medicine.
SUBSTANCE: present invention refers to immunology. Presented is an antibody able to bind to an amplified epidermal growth factor receptor (EGFR) and to de2-7 EGFR, a truncated version of EGFR, and characterised by sequences of variable domains. There are also disclosed a kit for diagnosing a tumour, an immunoconjugate, pharmaceutical compositions and methods of treating a malignant tumour based on using the antibody according to the invention, as well as a single-cell host to form the antibody according to the present invention.
EFFECT: invention can find further application in diagnosing and treating cancer.
43 cl, 98 dwg, 20 tbl, 26 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SPECIFIC BINDING PROTEINS AND APPLICATIONS THEREOF | 2010 |
|
RU2673724C2 |
| COMPOSITIONS OF RECOMBINANT ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES | 2008 |
|
RU2488596C2 |
| COMPOSITIONS OF RECOMBINANT ANTIBODIES FROM EPIDERMAL GROWTH FACTOR RECEPTOR | 2009 |
|
RU2540146C2 |
| TREATMENTS OF CANCER EXPRESSING MUTANT EGF RECEPTORS | 2007 |
|
RU2429014C2 |
| ANTIBODIES BOUND TO EXTRACELLULAR DOMAIN OF TYROSINE KINASE RECEPTOR (ALK) | 2007 |
|
RU2460540C2 |
| TREATING PATIENTS DIAGNOSED WITH PANCREATIC DUCT ADENOCARCINOMA WITH USING EPIDERMAL GROWTH FACTOR (EGFR) RECEPTOR MONOCLONAL ANTIBODIES | 2016 |
|
RU2728571C2 |
| HUMAN ANTIBODIES TO RECEPTOR OF EPIDERMAL GROWTH FACTOR | 2005 |
|
RU2402569C2 |
| TUMOR-SPECIFIC ANTI-EGFR ANTIBODY AND USE THEREOF | 2016 |
|
RU2730605C2 |
| EPITOPES OF EPIDERMAL GROWTH FACTOR RECEPTOR SURFACE ANTIGEN AND USE THEREOF | 2013 |
|
RU2650770C2 |
| MONOCLONAL ANTI-CLAUDIN-18 ANTIBODIES FOR TREATING CANCER | 2008 |
|
RU2571923C2 |
