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(19)

(11)

2 488 596

(13)

(51)

IPC

C07K16/28(2006-01-01)

C07K14/71(2006-01-01)

C12N5/00(2006-01-01)

A61K39/395(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2009136340/10, 2008-02-27

(24)

Start date

2008-02-27

(22)

Actual filing date

2008-02-27

(45)

Published

2013-07-27

(72)

Inventor

Pedersen Mikkel' Vannakhl'Stejno LusillaEnsen AllanKofod KlausMejer Per-JokhanKarlsson RobertPajk Charl'ZNil'Sen Lars Sogor

(73)

Holder

Simfogen A/S

COMPOSITIONS OF RECOMBINANT ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES Russian patent published in 2013 - IPC C07K16/28 C07K14/71 C12N5/00 A61K39/395 A61P35/00

Abstract RU 2488596 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to immunology. What is presented is a composition containing at least two antibodies which bind different epitopes of human EGFR (ErbB-1) thereby providing a synergetic effect; what is also presented is a bi-specific molecule representing an antibody or a fragment thereof containing sequences of CDR antibodies as a part of the composition according to the invention. What is considered is the use of the composition according to the invention for preparing a drug and a pharmaceutical composition containing the composition according to the invention.

EFFECT: composition according to the present invention provides a synergetic effect of anti-EGFR antibodies that can find further application in treating cancer.

20 cl, 17 tbl, 21 ex, 42 dwg

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RU 2 488 596 C2

Authors

Pedersen Mikkel' Vannakhl'

Stejno Lusilla

Ensen Allan

Kofod Klaus

Mejer Per-Jokhan

Karlsson Robert

Pajk Charl'Z

Nil'Sen Lars Sogor

Dates

2013-07-27—Published

2008-02-27—Filed