METHOD FOR INDIVIDUAL SELECTION OF IMMUNOCORRECTIVE THERAPY FOR PREVENTION OF FREQUENT RESPIRATORY INFECTIONS IN PRIMARY SCHOOL-AGED CHILDREN Russian patent published in 2015 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: children are divided into 4 groups; the first group includes the children having the following symptoms: short period of breastfeeding in the medical history, frequently ill family members, no complications of respiratory infections, IgA from 0.7 to 1.1 mg/ml, IgG from 10.6 to 16.2 mg/ml; the second group: mother's gestosis during the pregnancy, threatening miscarriage in the medical history, frequent complications of respiratory diseases - sinusitis, otitis; alpha2-globulin from 9.4 to 11.8 g/l, gamma-globulin from 17.8 to 22.6 g/l, TNF-α from 8.7 to 10.1 pg/ml, IgG from 16.7 to 23.7 mg/ml, CD3+ from 51 to 56.2%, CD4+ from 27.2 to 29.4%, CD16+CD56+ from 6.5 to 8.5%, nitro blue tetrazolium reduction test from 25 to 32.8%; the third group: mother's anaemia during the pregnancy, child's positive endocrine heredity, respiratory diseases frequently complicated with bronchitis, Candida seeding in throat swabs, gamma globulins from 12.1 to 14.9 g/l, IgG from 10.9 to 15.5 mg/ml, CD19+ from 7.6 to 9.6%, nitro blue tetrazolium reduction test from 25.5 to 31.7%; the fourth group: allergic reactions in the child's medical history, positive allergic heredity, respiratory diseases frequently complicated with obstructive bronchitis, gamma globulins from 18.1 to 23.1 g/l, IgE from 67 to 261 IU/ml. Acute respiratory diseases are prevented by Multitabs, a vitamin mineral complex, and one of the immunocorrective preparations: in the first group with IRS-19, a preparation of bacterial lysates; in the second group with a preparation of glucosaminyl muramyl dipeptide (Licopid); in the third group with a preparation of azoximer bromide (polyoxidonium); in the fourth group the immunocorrection is not recommended.

EFFECT: using the given method enables selecting a variant of immunocorrection depending on the presence or absence of diagnostic signs.

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