FIELD: chemistry.
SUBSTANCE: claimed invention relates to a method of obtaining methyl ether of 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionic acid 
and benzosulphonate of methyl ether of 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionic acid, which includes the interaction of methyl ether of 3-[(S)-7-bromo-2-((R and/or S)-2-hydroxypropylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid 
with an oxidiser and, optionally, processing the reaction product in acidic conditions, as well as to intermediate compounds 
and 
.
EFFECT: simplification and reduction of the price of the obtaining method due to the reduction of the number of stages.
13 cl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| IMIDAZODIAZEPINES, METHOD OF THEIR SYNTHESIS AND DRUG | 1995 |
|
RU2139873C1 |
| TRICYCLIC DIAZEPINE VASOPRESSIN AND OXYTOCIN ANTAGONISTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT | 1994 |
|
RU2126006C1 |
| NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND COSMETICS | 2015 |
|
RU2712971C2 |
| BICYCLIC LACTAMS AND METHODS FOR USE THEREOF | 2016 |
|
RU2716136C2 |
| 5-HETEROCYCLO-1,5-BENZODIAZEPINES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1995 |
|
RU2152939C1 |
| TRIAZOLO (4,3-a) 1,4 BENZO DIAZEPINES AND THRENO (3,2 | 1992 |
|
RU2094436C1 |
| DERIVATIVES OF DIAZEPINE, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF PATIENTS WITH ARRYTHMIA | 1994 |
|
RU2155587C2 |
| HETEROARYL COMPOUNDS, COMPOSITIONS CONTAINING THEM AND METHODS OF TREATING WITH USE OF SUCH COMPOUNDS | 2007 |
|
RU2478635C2 |
| DERIVATIVE OF PYRIMIDINE AND A FIVE-MEMBERED NITROGEN-CONTAINING HETEROCYCLE, METHOD FOR PRODUCTION AND MEDICAL APPLICATIONS THEREOF | 2019 |
|
RU2775229C1 |
| BENZOXAZEPINE PI3K INHIBITORS AND METHODS OF USE | 2010 |
|
RU2600927C2 |
