PROTEINS BINDING PROSTAGLANDIN E2 AND USING THEM Russian patent published in 2015 - IPC C07K16/18 C12N15/13 C12N15/63 C12N5/10 A61K39/395 A61P9/00 A61P11/00 

FIELD: medicine.

SUBSTANCE: present invention refers to immunology. There are also disclosed: a recovered nucleic acid coding an antibody or its antigen-binding fragment, an expression vector, a host cell, a method for producing the antibody or its antigen-binding fragment according to the invention, compositions containing the antibody or antigen-binding antibody fragment according to the invention, using the antibody or antigen-binding fragment according to the invention in producing a medicinal agent for reducing PGE₂ activity in a subject individual and for treating the individual, as well as a method for detecting PGE₂ or its fragment in a test sample by immunoassay. The present invention can find further application in therapy and diagnosis of the diseases related to PGE₂ hyperactivity or overexpression.

EFFECT: there are presented the antibody and its antigen-binding fragment binding prostaglandin E₂ (PGE₂) and characterised by CDR sequences.

25 cl, 9 dwg, 21 tbl, 4 ex