FIELD: medicine.
SUBSTANCE: invention refers to a method for producing thyroid hormones of formula
The method involves carrying out a reaction of a compound of formula with an iodinating agent containing NaI and I2 in the presence of aliphatic amine to produce a disodium derivative of formula II as a raw material. The produced alcohol water alkaline solution of the compound of formula II having pH at least 11 is heated to a temperature of 40°C to 80°C, cooled down to a temperature of 5°C to 20°C, and the compound II is recovered as a pure solid material.
EFFECT: presented method enables the one-stage production of high-yield and high-purity disodium salt II.
14 cl, 1 tbl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
PROCESS FOR PREPARATION OF LEVOTHYROXINE AND SALTS THEREOF | 2015 |
|
RU2673540C2 |
METHOD OF PRODUCING SULPHATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE | 2012 |
|
RU2662826C1 |
METHOD OF PRODUCING SULPHATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE | 2012 |
|
RU2610093C2 |
METHOD OF PRODUCING SULPHATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE | 2018 |
|
RU2708244C1 |
METHOD OF IODINATION OF AROMATIC COMPOUNDS | 2010 |
|
RU2506254C2 |
CRYSTALLINE FORMS OF MONOSODIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN | 2008 |
|
RU2476440C2 |
CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND MONOAMMONIUM SALT OF D-ISOGUTAMYL-D-TRYPTOPHAN | 2007 |
|
RU2483077C2 |
PHARMACEUTICAL COMPOSITION, CONTAINING N-ACYL DERIVATIVES OF AMINO ACIDS, AND THEIR APPLICATION AS ANTI-ALLERGIC, ANTI-ANAPHYLACTIC AND ANTI-INFLAMMATORY MEDICATIONS | 2008 |
|
RU2406727C2 |
METHOD OF PRODUCING N-ACYL DERIVATIVES OF AMINO ACIDS (VERSIONS) | 2008 |
|
RU2378284C2 |
PHARMACEUTICALLY ACCEPTABLE THYMODEPRESSIN SALTS AND METHOD OF OBTAINING THEREOF | 2007 |
|
RU2536685C2 |
Authors
Dates
2015-08-20—Published
2010-12-17—Filed