FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to immunology. What is presented is a recovered peptide having an ability to induce cytotoxic T-lymphocytes (CTL) in the presence of antigen-presenting cells (APS) carrying HLA-A*2402, and representing a fragment of FOXM1 protein. There are also disclosed: the recovered polynucleotide coding the peptide according to the invention; a composition for CTL induction and a pharmaceutical composition for treating and/or preventing cancer expressing FOXM1, and/or preventing its postoperative recurrences, containing the peptide according to the invention as an agent; methods for APS and CTL induction; the recovered APS having an ability to induce CTL; as well as a method for inducing the immune response to cancer expressing FOXM1 in an individual.
EFFECT: invention provides inducing the immune response to cancer expressing FOXM1 that can find further application in therapy of various diseases, including malignant ones relates to higher expression of FOXM1 protein.
11 cl, 3 dwg, 2 tbl
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