FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to medicine. A therapeutic agent for corneal endothelial dysfunction containing (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide <Y-39983> or its pharmacologically acceptable salt (compound (Ia)) as an active ingredient, an agent for corneal endothelial cell adhesion stimulation containing the compound (Ia), a corneal endothelial cell culture medium containing the agent for adhesion stimulation, a corneal graft for endothelial keratoplasty comprising corneal endothelial cells, a frame and the compound (Ia), and a method for producing a corneal endothelial preparation involving the stage of corneal endothelial cell culture with the use of the culture medium.
EFFECT: agent is used for the effective and comfortable treatment of the diseases involving the corneal endothelial cell damage accompanied by in vivo proliferation impairment.
21 cl, 17 dwg, 10 ex
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