PHARMACEUTICAL COMPOSITION WITH ANALGESIC ACTIVITY IN INJECTION FORM (VERSIONS) Russian patent published in 2015 - IPC A61K31/4188 A61K47/00 A61K9/08 A61P23/00 A61P23/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: pharmaceutical composition with kappa-opioid agonistic activity, demonstrating an analgesic effect in accordance with the first version contains 9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo[1,2-α]benzimidazole dihydrochloride as an active component, and an isotonicity corrigent, selected from salts of organic and inorganic acids, polyols, amino acids, as auxiliary substances. The composition can additionally contain a co-solvent, a corrigent of the solution pH, a cryoprotector, and an antioxidant. In accordance with the second version the pharmaceutical composition contains 9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo[1,2-α]benzimidazole dihydrochloride as an active component, and a co-solvent, selected from ethyl alcohol, glycerol, propylene glycol, benzylbenzoate, benzyl alcohol, ethyloleate and fatty oils, including olive oil and peach oil as auxiliary substances. The composition can additionally contain an isotonicity corrigent, a corrigent of the solution pH, a cryoprotector, and an antioxidant.

EFFECT: invention provides the pharmaceutical composition in an injection form with kappa-opioid agonistic activity without narcogenic potential, demonstrating the fast relief of pain syndrome.

12 cl, 5 dwg, 3 tbl, 4 ex