STABLE PHARMACEUTICAL COMPOSITION BASED ON ACTINOMYCIN D FOR INJECTIONS Russian patent published in 2016 - IPC A61K38/12 A61K47/26 A61K9/08 A61P35/00

Abstract RU 2587716 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to medicine, chemical and pharmaceutical industry, namely to compounds having anticancer activity, and concerns obtaining an injectable dosage form of actinomycin D. Described is the pharmaceutical formulation for injections in the form of a solution which contains actinomycin D dissolved in 0.2 % sodium hydroxide or a phosphate buffer with pH 6.5-7.5 as an active ingredient and carbohydratethe as an auxiliary substance, selected from mannitol and dextrose, and water for injections in quantities specified in the patent claim. Invention extends the range of liquid forms of actinomycin D-based preparations for injections.

EFFECT: disclosed formulation is stable and is prepared without adding stabilisers such as metabisulphite, sodium bisulphite, Trilon B.

3 cl, 1 tbl, 5 ex

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RU 2 587 716 C2

Authors

Kruglyj Boris Igorevich

Tyulyaev Aleksandr Ivanovich

Sukoyan Galina Viktorovna

Dates

2016-06-20—Published

2014-01-14—Filed