PHARMACEUTICAL COMPOSITION OF NEUROPROTECTIVE ACTION FOR PARENTERAL APPLICATION ON BASIS OF HEXAMETHYLENEDIAMINE BIS-(N-MONOSUCCINYL-L-GLUTAMIL-L-LYSINE) IN LYOPHILIZED DOSAGE FORM Russian patent published in 2019 - IPC A61K9/19 A61K38/05 A61K47/10 A61P25/28 

Abstract RU 2678203 C2

FIELD: medicine; pharmacy.

SUBSTANCE: invention relates to medicine and pharmacy and relates to a pharmaceutical composition of neuroprotective action in the form of a lyophilisate for the manufacture of injection or infusion dosage forms containing as an active ingredient hexamethylenediamine bis-(N-monosuccinyl-L-glutamyl-L-lysine) and lyoprotectants and cryoprotectants in a certain quantitative ratio of the components used as functional additives, when using the recommended modes of drying and freezing.

EFFECT: implementation of the invention allows to create a stable dosage form, optimal for storage and use, and also to receive the preparation providing increase in duration of a finding of a dipeptide in a system blood-groove in comparison with its substance.

5 cl, 4 tbl, 11 ex

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RU 2 678 203 C2

Authors

Seredenin Sergej Borisovich

Gudasheva Tatyana Aleksandrovna

Alekseev Konstantin Viktorovich

Blynskaya Evgeniya Viktorovna

Tishkov Sergej Valerevich

Mikheeva Anna Sergeevna

Povarnina Polina Yurevna

Durnev Andrej Dmitrievich

Zherdev Vladimir Pavlovich

Dates

2019-01-24Published

2017-05-30Filed