HUMANISED ANTIBODIES TO Toll-LIKE RECEPTORS 2 AND THEIR APPLICATIONS Russian patent published in 2015 - IPC C07K16/28 C12P21/08 A61K39/395 A61P37/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of immunology. Claimed isolated antibody or its antigen-binding part, which contains variable region of light chain and variable region of heavy chain with amino acid sequences, disclosed in description, or with amino acid sequences of variable regions, at least by 90% identical to said sequences, where variable region of light chain contains CDR1: RASESVEYYGTSLMQ, CDR2: GASNVES and CDR3: QQSRKLPWT, and variable region of heavy chain contains CDR1: TYGIN, CDR2: WIYPRDGSTNFNENFKD and CDR3: LTGGTFLDY, where antibody or its antigen-binding part specifically bind extracellular domain of Toll-like receptor 2 and are an antagonist to function of Toll-like receptor 2. Also described are isolated nucleic-acid molecule, which codes said antibody and antigen-binding part; expression vector, which contains said nucleic-acid molecule; and host cell for obtaining antigen by claimed invention, which contains said expression vector. Claimed is application of said antigen or antigen-binding part in production of medication for treatment of inflammatory, pulmonary or autoimmune condition or disease, mediated by activation of Toll-like receptor 2. Disclosed is method of production of antibody to Toll-like receptor 2 or its antigen-binding part by claimed invention, which includes stages of expression of antibody or antigen-binding part in host cell and isolation of antigen or antigen-binding part from cell-host.

EFFECT: invention makes it possible to extend arsenal of means, which represent inhibiting antibodies to Toll-like receptor 2.

23 cl, 27 dwg, 1 tbl, 14 ex