FIELD: biotechnology.
SUBSTANCE: transporter module across the blood-brain barrier containing a molecule to be transported to the brain through the blood-brain barrier, and one monovalent antibody against the transferrin receptor or a fragment thereof that binds the transferrin receptor are proposed. The invention also relates to a pharmaceutical composition comprising the said carrier module and to the use of the carrier module for transporting a molecule to be transported to the brain.
EFFECT: invention can be used in medicine for efficient transport of an effector molecule across the blood-brain barrier.
12 cl, 1 dwg, 1 tbl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MONOVALENT CARRIER MODULES ACROSS BLOOD-BRAIN BARRIER | 2014 |
|
RU2694659C2 |
| HUMANISED HUMAN CD19 ANTIBODIES AND METHODS FOR USE THEREOF | 2016 |
|
RU2731156C1 |
| BISPECIFIC ANTI-HAPTEN/ANTI-BLOOD BRAIN BARRIER RECEPTOR ANTIBODIES, COMPLEXES THEREOF AND THEIR USE AS BLOOD BRAIN BARRIER SHUTTLES | 2014 |
|
RU2693438C2 |
| ANTIBODIES AGAINST 5-BROMO-2'-DEOXYURIDINE AND METHODS OF USE | 2015 |
|
RU2705299C2 |
| ANTIBODIES TO ALPHA-SYNUCLEIN AND METHODS OF USING | 2014 |
|
RU2697098C1 |
| ANTIBODIES TO ALPHA-SYNUCLEIN AND METHODS OF USING | 2014 |
|
RU2718990C1 |
| ANTIBODIES AGAINST TRANSFERRIN RECEPTOR HAVING INDIVIDUALIZED AFFINITY | 2016 |
|
RU2729416C2 |
| BLOOD BRAIN BARRIER SHUTTLE | 2013 |
|
RU2663120C2 |
| BISPECIFIC ANTIBODIES SPECIFIC TO PD1 AND TIM3 | 2016 |
|
RU2729371C1 |
| COVALENTLY LINKED CONJUGATES CHELICAR-ANTIBODY AGAINST CHELICAR AND USE THEREOF | 2014 |
|
RU2694981C2 |
