CATECHOL-O-METHYLTRANSFERASE INHIBITORS AND THEREOF APPLICATION FOR TREATMENT OF PSYCHOTIC DISORDERS Russian patent published in 2015 - IPC C07D401/04 C07D401/10 A61K31/44 A61P25/18 

FIELD: chemistry.

SUBSTANCE: invention relates to 4-pyridinone compounds of formula I: , where Y represents CN, C_2-6-alkinyl, (CH₂)_nC_5-10-heterocyclyl, (CH₂)_nC_6-10-aryl, with said alkinyl, heterocyclyl and aryl being substituted with 1-3 groups R^a; X, X¹ and R¹ independently represent hydrogen, halogen, CN, C_1-6-alkyl, with said alkyl being optionally substituted with 1-3 groups R^a; R² represents H, OH, C_1-6-alkyl, (CH₂)_nC_3-10-cycloalkyl, (CH₂)_nC_5-10-heterocyclyl, (CH₂)_nC_6-10-aryl, with said aryl and heterocyclyl being optionally substituted with 1-3 groups R^a; R^a represents C_1-6-alkyl, halogen, CF₃, OCF₃, NR²C(O)R², C(O)N(R²)₂, C(O)R², CN, NHSO₂R², OR², (CH₂)_nC_5-10-heterocyclyl, (CH₂)_nC_6-10-aryl, with said alkyl, heterocyclyl and aryl being optionally substituted with 1-3 groups R^b; R^b represents halogen; and n represents integer number from 0 to 2, which are catechol-O-methyltransferase (COMT) inhibitors.

EFFECT: obtaining 4-pyridinone compounds.

14 cl, 1 tbl, 16 ex