NOVEL HETEROCYCLIC COMPOUNDS AS BRD4 INHIBITORS Russian patent published in 2020 - IPC C07D491/04 C07D471/04 A61K31/55 A61K31/4353 A61P35/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a tautomeric form thereof, a stereoisomer, a solvate or a pharmaceutically acceptable salt thereof, where in said formula ---- is a single bond or a double bond; X is selected from -O- or -N-; n equals 0–1; R ₁ is C₁-C₈-alkyl; R₂ and R₃ are selected independently from hydrogen, halogen, hydroxy, C₁-C₈-halogenalkyl, independently substituted with up to three halogen atoms selected from fluorine, chlorine, bromine or iodine, C₁-C₈-alkoxy, C₁-C₈-haloalkoxy; R₄ is selected from C₁-C₈-alkyl, C₃-C₈-cycloalkyl, C₃-C₈-cycloalkylalkyl, C₆-C₁₈-aryl, C₂-C₁₈-heteroaryl or C₁-C₈-haloalkyl, where alkyl, cycloalkyl, cycloalkylalkyl, aryl and heteroaryl independently are unsubstituted or substituted by up to three substituents independently selected from halogen, C₁-C₈-alkyl and cyano, and where heteroaryl contains up to three heteroatoms selected from O, N or S atoms; Z is selected from hydrogen, -CH₂OR₅, -COOR₅, -CONR₅R₆, -NHCOOR₅ or -NHCOR₅, where R₅ and R₆ are independently selected from hydrogen, C₆-C₁₈-aryl or C₁-C₈-alkyl; where R₅ and R₆ are optionally substituted with one or more substitutes selected from hydroxy, oxo (=O) or C₁-C₈-alkyl. Invention also relates to a pharmaceutical composition based on said compounds.

I.

EFFECT: novel compounds and a pharmaceutical composition based thereon, which can be used in medicine for treating cancer.

17 cl, 1 tbl, 46 ex