FIELD: chemistry; pharmaceutics.
SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof:
as well as a compound of formula (I-a) or a pharmaceutically acceptable salt thereof:
a compound represented by the following formula (Id), or a pharmaceutically acceptable salt thereof:
specific compounds selected from the group, a pharmaceutical composition, a method of preparing a pharmaceutical composition and use of compounds of formula (I) and (I-a) for preparing a medicinal agent for treating a condition or disorder mediated by TRPV4 receptor antagonist activity.
EFFECT: obtaining novel compounds which can be used as TRPV4 receptor modulators for treating a wide range of diseases, syndromes and disorders, in particular for the treatment of inflammatory, pain and urological diseases or disorders.
18 cl, 277 tbl, 1105 ex
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