FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to anti-tumour compounds: 3'-deamino-3"-4'-anhydro-[2"(S)-methoxy-3"(R)-hydroxy-4"-morpholinyl]-idarubicin, 3'-deamino-3"-4'-anhydro-[2"(S)-methoxy-3"(R)-hydroxy-4"-morpholinyl]-daunorubicin, 3'-deamino-3"-4'-anhydro-[2"(S)-methoxy-3"(R)-hydroxy-4"-morpholinyl]-carminomycin and 3'-deamino-3"-4'-anhydro-[2"(S)-ethoxy-3"(R)-hydroxy-4"-morpholinyl]-doxorubicin, their pharmaceutically acceptable acid addition salts and a method of obtaining formula
compound or its pharmaceutically acceptable acid addition salts by the interaction of cyanuric chloride with an N-oxide derivative of formula
,
where R1 is H, OH or OCH3; R 2 is H or OH, R3 is H or C1-C5-alkoxy.
EFFECT: claimed are novel effective anti-tumour medications and methods of obtaining thereof, making it possible to obtain formula (I) compound with good output and purity.
7 cl, 1 ex, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANTHRACYCLINE GLYCOSIDES AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS, METHOD OF THEIR SYNTHESIS, DIIODOINTERMEDIATE COMPOUND AND METHOD OF ITS SYNTHESIS | 1991 |
|
RU2100366C1 |
| MACROHETEROCYCLIC NUCLEOSIDE DERIVATIVES AND ANALOGUES THEREOF, PRODUCTION AND USE | 2017 |
|
RU2731385C1 |
| ANTHRACYCLINE GLYCOSIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS SHOWING ANTITUMOR PROPERTIES, AND A METHOD OF THEIR SYNTHESIS | 1990 |
|
RU2043360C1 |
| COMPOUNDS OF C, O-SPIRO-ARYLGLYCOSIDES, THEIR PREPARATION AND USE | 2016 |
|
RU2746858C2 |
| QUINOLINE-2 DERIVATIVES AS C-KIT KINASE INHIBITORS | 2016 |
|
RU2754858C2 |
| ARGINASE INHIBITORS AND THERAPEUTIC USE THEREOF | 2011 |
|
RU2586219C2 |
| FURO[3,2-B]- AND THIENO[3,2-B]PYRIDINE DERIVATIVES AS TBK1 AND IKKε INHIBITORS | 2013 |
|
RU2622034C2 |
| SUBSTITUTED BENZENE COMPOUNDS | 2013 |
|
RU2658919C2 |
| NAPHTHYLACETIC ACIDS | 2009 |
|
RU2539185C2 |
| TRIAZOLO-PYRIMIDINE COMPOUNDS AND THEIR USE | 2019 |
|
RU2802866C2 |
