SUBSTITUTED BENZENE COMPOUNDS Russian patent published in 2018 - IPC C07D213/50 C07D213/64 C07D401/12 C07D405/12 C07D413/12 C07D413/14 A61K31/4412 A61K31/444 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to substituted benzene compounds represented by formulae I, III, VI, VII. Compound of formula III:

,

or a pharmaceutically acceptable salt thereof, where R⁸⁰¹ is C_1-6 alkyl, C_2-6 alkynyl, heterocycloalkyl, selected from morpholine, pyrrolidine, tetrahydrothiophene, piperidine, piperazine, oxetane, pyran, tetrahydropyran, azetidine and tetrahydrofuran, phenyl or heteroaryl, selected from pyrrole, furan, thiophene, thiazole, isothiazole, imidazole, triazole, tetrazole, pyrazole, oxazole, isoxazole, pyridine, pyrazine, pyridazine and pyrimidine, each of which contains, as a substituent, OC_1-6 alkyl-R_x, where R_x is hydroxyl or OC_1-3 alkyl and R_x optionally further substituted with OC_1-3 alkyl; each of R⁸⁰² and R⁸⁰³ independently is H, halogen, C_1-4 alkyl or C_1-6 alkoxy; each of R⁸⁰⁴ and R⁸⁰⁵ is independently C_1-4 alkyl; and R⁸⁰⁶ is -Q_x-T_x, where Q_x is a bond or C_1-4 alkyl linking group, T_x is H, tetrahydropyranyl, piperidinyl substituted with 1, 2 or 3 C_1-4 alkyl groups, or cyclohexyl, containing, as a substituent, N(C_1-4 alkyl)₂, where one or both C_1-4 alkyl optionally have as substituent C_1-6 alkoxy; which have the ability to inhibit the activity of EZH2, as well as to pharmaceutical compositions containing said compounds and methods of treatment.

EFFECT: treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.

55 cl, 7 tbl, 3 ex