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RU

(11)

2 563 639

(13)

C2

(51)

IPC

C07D207/34(2006-01-01)

C07D261/18(2006-01-01)

C07D263/34(2006-01-01)

C07D277/56(2006-01-01)

C07D307/68(2006-01-01)

C07D333/38(2006-01-01)

C07D417/12(2006-01-01)

C07D417/14(2006-01-01)

A61K31/341(2006-01-01)

A61K31/381(2006-01-01)

A61K31/40(2006-01-01)

A61K31/42(2006-01-01)

A61K31/426(2006-01-01)

A61K31/427(2006-01-01)

A61K31/44(2006-01-01)

A61K31/4439(2006-01-01)

A61K31/454(2006-01-01)

A61K31/496(2006-01-01)

A61K31/541(2006-01-01)

A61P13/00(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2012116505/04, 2010-09-24

(24)

Start date

2010-09-24

(22)

Actual filing date

2010-09-24

(45)

Published

2015-09-20

(72)

Inventor

Kavaminami EhjdziTakakhasi TatsukhisaKanajama TakatosiFukuda JutaKaizava KhirojukiKondokh JutakaSeo RjusiKuramoto KazujukiTake KazukhikoSakamoto Kazujuki

(73)

Holder

Astellas Farma Ink.

SUBSTITUTED AMIDE COMPOUNDS Russian patent published in 2015 - IPC C07D207/34 C07D261/18 C07D263/34 C07D277/56 C07D307/68 C07D333/38 C07D417/12 C07D417/14 A61K31/341 A61K31/381 A61K31/40 A61K31/42 A61K31/426 A61K31/427 A61K31/44 A61K31/4439 A61K31/454 A61K31/496 A61K31/541 A61P13/00 A61P35/00 

Abstract RU 2563639 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to carboxamide derivatives, selected from: N-(aminosulphonyl)-2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxamide, 2-{[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-methyl}-N-[(ethylamino)sulphonyl]-1,3-thiazole-4-carboxamide, 2-{[(4-ethyl-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]-methyl}-5-methyl-N-[(methylamino)sulphonyl]-1,3-thiazole-4-carboxamide, 2-({[(5-methoxypyridin-2-yl)acetyl](3-phenylpropyl)-amino}methyl)-N-(dimethylsulphamoyl)-5-methyl-1,3-thiazole-4-carboxamide, N-(dimethylsulphamoyl)-2-[({[1-(5-methoxypyridin-2-yl)-cyclopropyl]carbonyl}[3-(5-methyl-2-furyl)propyl]amino)methyl]-5-methyl-1,3-thiazole-4-carboxamide and N-(dimethylsulphamoyl)-2-[([3-(3-fluorophenyl)propyl]{[1-(5-methoxypyridin-2-yl)cyclopropyl]carbonyl}amino)methyl]-5-methyl-1,3-thiazole-4-carboxamide. Invention also relates to pharmaceutical composition, application of said compounds and to method of prevention and/or treatment of diseases.

EFFECT: carboxamide derivatives, possessing antagonistic activity with respect to LPA-receptor.

13 cl, 138 tbl, 117 ex

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RU 2 563 639 C2

Authors

Kavaminami Ehjdzi

Takakhasi Tatsukhisa

Kanajama Takatosi

Fukuda Juta

Kaizava Khirojuki

Kondokh Jutaka

Seo Rjusi

Kuramoto Kazujuki

Take Kazukhiko

Sakamoto Kazujuki

Dates

2015-09-20—Published

2010-09-24—Filed

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