AMINOBENZOPHENONES Russian patent published in 2009 - IPC C07C225/22 C07C229/44 C07C233/40 C07C233/43 C07C235/10 C07C235/20 C07C235/74 C07C271/20 C07C271/22 C07C309/73 C07C311/09 C07C317/48 C07C323/52 C07D207/27 C07D233/74 C07D207/404 C07D295/135 C07D307/14 C07D309/12 C07D317/22 C07D317/28 C07D493/04 C07D493/14 A61K31/136 A61P35/00 A61P17/00 A61P29/00 A61P9/10 

FIELD: chemistry.

SUBSTANCE: invention relates to new derivatives of aminobenzophenones with general formula I with inhibition properties towards interleukin-1β(IL-1β) and tumour necrosis factor (TNF-α). In general formula I X is oxygen; R₁ is (C₁-C₃)alkyl, R₂ is one or more, identical or different substitutes, chosen from a group containing hydrogen and halogen; R₃ is one or more, identical or different substitutes, chosen from a group containing hydrogen and halogen, R₄ is hydrogen, R₅ is hydrogen, R₆ is (C₁-C₁₀)alkyl-heterocyclyl, (C₁-C₁₀)alkyl, (C₂-C₁₀)olefin group, heterocyclyl, Y₁R₂₁, Y₂R₂₂ or Y₄R₂₄; where (C₁-C₁₀)alkyl, (C₂-C₁₀)olefin group are substituted with one or more identical or different substitutes, represented by R₇ and where (C₁-C₁₀)alkyl-heterocyclyl, heterocyclyl are optionally substituted with one or more, identical or different substitutes, represented by R₇; heterocyclyl itself and in (C₁-C₁₀)alkyl-heterocyclyl represents a 5-6-member saturated or partially unsaturated heterocyclyl, possibly condensed with a benzene ring and containing 1-2 heteroatoms, chosen fron nitrogen, oxygen and sulphur.

EFFECT: compounds can be used for making medicinal preparation for curing and preventing diseases, related to cytokine regulation system, such as inflammatory diseases.

13 cl, 4 dwg, 3 tbl, 169 ex