AZABICYCLOCOMPOUND AND ITS SALT Russian patent published in 2015 - IPC C07D471/04 A61K31/437 A61K31/4709 A61K31/5377 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel azabicyclic compounds, represented by the given below general formula

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or to their pharmaceutically acceptable salts. The said compounds demonstrate inhibition activity with respect to HSP90 and action inhibiting cellular proliferation. In formula (I) X¹ represents CH or N; one of X², X³ and X⁴ represents N, and the others represent CH; one or two of Y¹, Y², Y³ and Y⁴ represent C-R⁴, one of the remaining ones represents CH or N and the remaining one represents CH; R¹ represents a monocyclic group optionally substituted 5- or 6-membered unsaturated heterocyclic group, which contains from 1 to 2 heteroatoms, selected from N, S and O, or an optionally substituted 9- or 10-membered bicyclic unsaturated heterocyclic group, which contains from 1 to 2 heteroatoms, selected from N, S and O, where the possible substituent is determined in the formula of the invention; R² represents a hydrogen atom, an optionally substituted with halogen atoms alkyl group, containing from 1 to 6 carbon atoms, or an alkenyl group, containing from 2 to 6 carbon atoms; and R³ represents CO-R⁵; R⁴ are similar or different and represent a hydrogen atom, a halogen atom, a cyanogroup, an alkyl group, which contains from 1 to 6 carbon atoms, optionally substituted with a mono- or di(C₁-C₆-alkyl)aminogroup or a morpholine group, a cycloalkyl group, which contains from 3 to 7 carbon atoms, an alkenyl group, which contains from 2 to 6 carbon atoms, an alkoxygroup, which contains from 1 to 6 carbon atoms, a phenyl group, -N(R⁶)(R⁷), -S-R⁸ or -CO-R⁹; R⁵ represents an aminogroup or mono- or di(C₁-C₆alkyl)aminogroup; R⁶-R⁹ have values, given in the invention formula.

EFFECT: invention relates to the pharmaceutical product, pharmaceutical composition and method of treating a cancer disease.

11 cl, 3 tbl, 191 ex