AMINOTRIAZOLOPYRIDINES AND USING THEM AS KINASE INHIBITORS Russian patent published in 2015 - IPC C07D471/04 A61K31/437 A61P29/00 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to compounds of formula (I), their pharmaceutically acceptable salts, tautomers or stereoisomers. In formula R¹ represents benzimidazolyl optionally substituted by C_1-4alkyl, C_1-4alkoxyC_1-4alkyl, hydroxyC_1-4alkyl, dimethylaminoC_1-4alkyl or oxo group; benzioxazolyl optionally substituted by C_1-4alkyl or amino group; benzotriazolyl optionally substituted by C_1-4alkyl; dihydrobenzisothiazol-1,1-dionyl; pyrimidyl; dihydroisoquinolinonyl optionally substituted by oxo group; imidazopyridyl; indazolyl optionally substituted by C_1-4alkyl, hydroxyC_1-4alkyl, C_1-4alkoxyC_1-4alkyl, tetrahydropyranylamino, piperidinylamino, halogen, trifluoromethyl or amino group; indolinyl optionally substituted by C_1-4alkyl, hydroxyC_1-4alkyl, carboxylate or oxo group; isoindolinyl optionally substituted by C_1-4alkyl, aminoC_1-4alkyl, hydroxyC_1-4alkyl, C_1-4alkoxyC_1-4alkyl or oxo group; phenyl optionally substituted by C_1-4alkyl, C_1-4alkoxy, halogen, cyano, trifluoromethyl, carbamoyl, methylcarbamoyl, piperidinylcarbamoyl, methylpiperidinylcarbamoyl, aminoC_1-4alkyl, carboxyl, amino, dialkylamino, imidazolyl, pyrrolidin-2-one, triazolyl, morpholinyl, C_1-4alkylcarbonylamino, C_1-4alkoxyC_1-4alkoxy or hydroxyC_1-4alkyl; pyrazolopyridyl optionally substituted by C_1-4alkyl; pyridyl optionally substituted by C_1-4alkyl, C_1-4alkoxy, halogen, cyano, hydroxy, amino, morpholinyl, carbamoyl, monoC_1-4alkylamino, diC_1-4alkylamino, aminoC_1-4alkoxy, aminoC_1-4alkylamino, hydroxypiperidinyl, hydroxyC_1-4alkyl, hydroxyC_1-4alkoxy, pyrrolidinylC_1-4alkylamino, pyrrolidinylC_1-4alkoxy; pyrrolopyridinyl optionally substituted by oxo group; quinolinyl optionally substituted by amino or hydroxy group; or triazolopyridyl substituted by C_1-4alkyl. The other radical values are presented in the patent claim. The invention also refers to individual compounds, to a pharmaceutical composition, possessing kinase inhibitory activity and containing an effective amount of the compound of the invention, to a method for kinase inhibition in a cell, to a method of treating or preventing inflammatory conditions, immunological conditions, allergic conditions, rheumatic conditions, cancer, and neuroinflammatory diseases.

EFFECT: there are prepared new compounds possessing Syk, FLT3, JAK1, JAK2 inhibitory activity.

21 cl, 1 tbl, 133 ex