GLP-1 ANALOGUE DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND THEREOF APPLICATION Russian patent published in 2015 - IPC C07K14/605 C07K19/00 A61K38/26 A61P3/10 A61P3/04 

FIELD: chemistry.

SUBSTANCE: invention relates to field of biotechnology, namely to obtaining derivatives of GLP-1 analogues, and can be used in medicine for treatment of insulin-independent diabetes mellitus, insulin-dependent diabetes mellitus or obesity. Amino acid sequences of GLP-1 analogues, containing lipophilic substituent of formula R₁(CH₂)_n-CO-, in which R₁ represents CH₃- or HOOC-, n represents integer number from 8 to 25, are obtained Lipophilic substituent is bound with ε amino group or α amino group Lys at GLP-1 analogue end by amide bond.

EFFECT: invention makes it possible to preserve human GLP-1 activity and increase period of half-life in vivo in comparison with human GLP-1.

12 cl, 6 tbl, 2 ex