IMPROVED COMPOSITION FOR INHIBITION OF TUMOUR CELL PROLIFERATION Russian patent published in 2015 - IPC C12N5/784 A61K48/00 A61P35/00

Abstract RU 2565542 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of biotechnology, in particular to obtaining stimulated dendritic cells (DC), and can be applied in medicine for immunotherapy of cancer. Mature pro-inflammatory DC is obtained by ex vivo induction of its maturation by processing immature DC with such substances as sodium salt of polyynosinic-polycytidinic acid (poly-Y:C), resiquimod (R848) and interferon-gamma (IFN-g), but not prostaglandin E2 (PGE2). Obtained DC is applied in treatment of cancer in individual by injection into tumour. Said pro-inflammatory mature DC is allogenic with respect to said individual.

EFFECT: invention makes it possible to efficiently inhibit proliferation of tumour cells.

14 cl, 14 dwg, 6 tbl

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RU 2 565 542 C2

Authors

Karlsson-Parra Aleks

Andersson Bengt

Vallgren Anna Karin

Dates

2015-10-20—Published

2011-02-10—Filed