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2 309 753

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IPC

A61K35/14(2006-01-01)

A61K35/28(2006-01-01)

A61P31/00(2006-01-01)

A61P37/00(2006-01-01)

A61P35/00(2006-01-01)

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Application

2006115473/15, 2006-05-05

(24)

Start date

2006-05-05

(22)

Actual filing date

2006-05-05

(45)

Published

2007-11-10

(72)

Inventor

Gol'Dshtejn Dmitrij VadimovichMakarov Andrej Vital'EvichArutjunjan Irina VladimirovnaFatkhudinov Timur KhajsamudinovichRzhaninova Alla Anatol'EvnaShamenkov Dmitrij AlekseevichGornostaeva Svetlana NikolaevnaVolkov Aleksej VadimovichBochkov Nikolaj Pavlovich

(73)

Holder

Zao

COMBINED CELL TRANSPLANT BASED ON LYMPHOKINE-ACTIVATED KILLERS AND DENDRITE CELLS, METHOD FOR PRODUCTION THEREOF AND METHOD FOR TREATMENT AND PROPHYLAXIS OF MALIGNANT, INFECTIVE DISEASES AND IMMUNODEFICIENT CONDITIONS Russian patent published in 2007 - IPC A61K35/14 A61K35/28 A61P31/00 A61P37/00 A61P35/00

Abstract RU 2309753 C1

FIELD: biopharmacology and medicine.

SUBSTANCE: disclosed is method for production of mononuclear blood cells, namely activated lymphocytes (ACL) and dendrite cells (DC). Claimed method includes a) isolation of mononuclear leucocytes (MNL) from blood and marrow of patient suffering from malignant neoplasm, or infective disease, or immunodeficient condition; d) incubation of isolated mononuclear lymphocytes in cultural medium; c) separation of MNL cultural bottles adhering to plastic and non-adhering thereto.; d) treatment of adhering MNL with growth factors to produce dendrite cells therefrom; e) treatment of DC with lysates from patient tumor; f) cultivation of non-adhered lymphocytes with interleukine-2 to produce ACL-cells. Also disclosed is method for treatment and prophylaxis malignant and infective diseases and immunodeficient conditions in patients by combined application of ACL-cells and dendrite cells.

EFFECT: new method for treatment and prophylaxis of malignant, infective diseases and immunodeficient conditions.

3 cl

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RU 2 309 753 C1

Authors

Gol'Dshtejn Dmitrij Vadimovich

Makarov Andrej Vital'Evich

Arutjunjan Irina Vladimirovna

Fatkhudinov Timur Khajsamudinovich

Rzhaninova Alla Anatol'Evna

Shamenkov Dmitrij Alekseevich

Gornostaeva Svetlana Nikolaevna

Volkov Aleksej Vadimovich

Bochkov Nikolaj Pavlovich

Dates

2007-11-10—Published

2006-05-05—Filed