METHOD OF PRODUCTION OF BIOMASS CONTAINING PLANTARICYNE AND ITS USE FOR MEDICAL PURPOSES Russian patent published in 2015 - IPC C12N1/20 A61K35/74 C12R1/225 C12R1/25 

FIELD: bioengineering.

SUBSTANCE: strain of lactobacillus Lactobacillus plantarum DSM 23213 and strain of lactobacillus Lactobacillus rossiae DSM 23214 are suggested, their joint cultivation activates synthesis of plantaricyne A, K and N and production of the product containing plantaricyne A, K and N. Product is produced by cultivation of the said strains, co-inoculation by water suspension of substrate lactobacillus, incubation at 30-37°C, preferably 30°C for 18-24 h, preferable 18 h. Said suspension has cell density about 9.0 log CFU/ml for each type of lactobacillus, and is added to the substrate in percentage ratio to volume of substrate from 1 to 4%. The produced product is used as part of pharmaceutical and cosmetic compositions, and during manufacturing of the medicament to increase barrier function of the epidermis or intestine, or for wound repair.

EFFECT: increased level of synthesis of plantaricyne A, K and N.

13 cl, 19 dwg, 3 ex