PHARMACEUTICAL FORMULATIONS CONTAINING CORTICOSTEROIDS FOR TOPICAL APPLICATION Russian patent published in 2015 - IPC A61K31/573 A61K31/56 A61K47/14 A61K9/06 A61P17/06 A61P17/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: pharmaceutical composition for topical skin application contains corticosteroid representing halobetasol propionate in the concentration of less than 0.5% and a liquid oily component containing one or more esters of monocarboxylic and dicarboxylic acids. Esters of dicarboxylic acids are specified in a group consisting of diethylsebacate and diisopropyladipate. Esters of monocarboxylic acids are specified in a group consisting of isopropylmyristate and isopropylpalmitate. The concentration of the above liquid oily component makes from 1.5 to 3 times required to dissolve the amount of the corticosteroid in the composition at temperature 22°C±2°C completely, whereas the concentration of the esters in the liquid oily component makes at least 10% of the concentrations of the liquid oily component in the composition. What is also described is a method of treating a skin disorder.

EFFECT: invention provides reducing side effects of using halobetasol.

21 cl, 7 tbl, 5 ex