FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to a novel crystalline form of an inhibitor of the sodium-dependent glucose cotransporter SGLT2 of formula 
, characterised by a powder X-ray diffraction pattern (XRDP) with the application of CuKα1 radiation, including peaks at 11.2, 12.9, 15.5, 17.8, 19.1, 20.0 and 20.7 degrees 2θ (±0.1 degree 2θ), spectrum of Raman scattering, including peaks at 353, 688, 825, 1178, 1205, 1212, 1608, 2945, 3010 and 3063 cm-1, as well as an endotherm, obtained by the method of differential scanning calorimetry (DSC), at 136°C, its obtaining by re-crystallisation from ethanol or methanol by the addition of water and based on it pharmaceutical compositions for treating diseases, the pathogenesis of which requires the inhibition of the sodium-dependent glucose cotransporter 2 (SGLT2).
EFFECT: claimed is the novel crystalline form of the biologically active substance with low hygroscopicity.
33 cl, 8 dwg, 5 tbl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SOLID FORMS (2S,3R,4R,5S,6R)-2-(4-CHLORO-3-(4-ETHOXYBENZIL)PHENYL)-6-(METHYLTHIO)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL AND METHODS FOR THEIR OBTAINING | 2009 |
|
RU2505543C2 |
| METHOD OF OBTAINING SGLT2 BENZYLENBENZOLE INHIBITORS | 2013 |
|
RU2625795C2 |
| CRYSTALLINE FORMS OF COMPLEXES USEFUL AS SGLT2 INHIBITORS, AND METHODS OF THEIR OBTAINING | 2014 |
|
RU2641905C2 |
| METHOD FOR PRODUCING DEPHENYLMETHANE DERIVATIVE | 2017 |
|
RU2797392C2 |
| BENZYL BENZENE DERIVATIVES AND METHODS FOR USING THEM | 2008 |
|
RU2497526C2 |
| METHOD OF PRODUCING DEPHENYLMETHANE DERIVATIVE | 2023 |
|
RU2814846C1 |
| COMPOSITIONS COMPRISING INHIBITORS OF SODIUM-GLUCOSE COTRANSPORTERS 1 AND 2 AND METHODS OF USING THEREOF | 2012 |
|
RU2669921C2 |
| BENZYL DERIVATIVES OF GLYCOSIDES AND METHODS OF THEIR APPLICATION | 2008 |
|
RU2492175C2 |
| C-GLYCOSIDE DERIVATIVES CONTAINING A CONDENSED PHENYL RING, OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, A METHOD OF PRODUCING SUCH AND A PHARMACEUTICAL COMPOSITION CONTAINING SUCH | 2017 |
|
RU2739024C2 |
| METHOD OF PRODUCING SGLT2 INHIBITORS | 2009 |
|
RU2530494C2 |
