CRYSTALLINE FORMS OF COMPLEXES USEFUL AS SGLT2 INHIBITORS, AND METHODS OF THEIR OBTAINING Russian patent published in 2018 - IPC C07D309/10 C07H7/04 A61K31/353 A61P3/10

Abstract RU 2641905 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the crystalline form of the complex (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-ylpropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, bis(L-proline) characterized by an X-ray powder diffraction pattern comprising peaks at 4.08, 17.19, and 21.12 degrees 2θ (±0.05 degrees 2θ), wherein the said X-ray powder diffraction pattern is obtained using CuKα₁ radiation.

EFFECT: provided complex has an inhibitory effect on the sodium-dependent SGLT transporter.

7 cl, 1 tbl, 3 dwg, 7 ex

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RU 2 641 905 C2

Authors

Liu Dzhejson

U Yuelin

Li Shenbin

Syuj Ge

Dates

2018-01-23—Published

2014-03-19—Filed