OBTAINING (3aS, 7aR)-HEXAHYDROISOBENZOFURAN-1(3H)-ONE BY CATALYTIC BIOLOGICAL CLEAVAGE OF DIMETHYLCYCLOHEXANE-1,2-DICARBOXYLATE Russian patent published in 2015 - IPC C12P17/04 C07D307/78 C12N9/16

Abstract RU 2570635 C2

FIELD: biotechnology.

SUBSTANCE: method of obtaining (3aS,7aR)-hexahydroisobenzofuran-1(3H)-one. Cis-dimethylcyclohexane-1,2-dicarboxylate is hydrolysed in the presence of an enzyme derived from non-mammalians and having the sequence of SEQ ID No. 1, SEQ ID No. 2 or SEQ ID No. 3 to obtain (1S,2R)-2-(methoxycarbonyl)cyclohexanecarboxylic acid. Then reductive cyclization of (1S,2R)-2-(methoxycarbonyl)cyclohexanecarboxylic acid is carried out in the presence of C₁-C₆-alkyl chloroformate followed by reduction with boron hydride to obtain (3aS,7aR)-hexahydroisobenzofuran-1(3H)-one.

EFFECT: invention enables to obtain the target product with a value of an enantiomeric excess greater than 95 percent.

7 cl, 3 ex

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RU 2 570 635 C2

Authors

Llojd Majkl Charl'Z

Dates

2015-12-10—Published

2011-05-24—Filed