METHOD FOR PRODUCING EX VIVO SOLUBLE FIBRINOGEN Russian patent published in 2015 - IPC A61K38/36 G01N33/49 

Abstract RU 2571288 C1

FIELD: medicine.

SUBSTANCE: fresh-frozen plasma is unfrozen and centrifuged; the produced cryoprecipitate is solubilised and treated with aluminium hydroxide; the produced suspension is centrifuged; the produced deposit containing non-target proteins are rejected; the supernatant is treated with polyethylene glycol; the suspension is centrifuged; the supernatant is rejected; the deposit is solubilised and subject to viral inactivation, cleaned from viral inactivation products by shaking with Vaseline oil and re-precipitating with glycerol; the deposit procedure is repeated twice; the produced fibrinogen solution is bottled and lyophilised.

EFFECT: producing fibrinogen, which possesses fast solubility.

2 ex, 2 dwg, 3 tbl

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RU 2 571 288 C1

Authors

Uvarov Valentin Jur'Evich

Ljashenko Alla Anatol'Evna

Popova Ol'Ga Petrovna

Ivanov Aleksej Alekseevich

Dates

2015-12-20Published

2014-08-19Filed