FIELD: medicine.
SUBSTANCE: fresh-frozen plasma is unfrozen and centrifuged; the produced cryoprecipitate is solubilised and treated with aluminium hydroxide; the produced suspension is centrifuged; the produced deposit containing non-target proteins are rejected; the supernatant is treated with polyethylene glycol; the suspension is centrifuged; the supernatant is rejected; the deposit is solubilised and subject to viral inactivation, cleaned from viral inactivation products by shaking with Vaseline oil and re-precipitating with glycerol; the deposit procedure is repeated twice; the produced fibrinogen solution is bottled and lyophilised.
EFFECT: producing fibrinogen, which possesses fast solubility.
2 ex, 2 dwg, 3 tbl
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Authors
Dates
2015-12-20—Published
2014-08-19—Filed