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IPC

A61K35/14(2015-01-01)

C12N9/74(2006-01-01)

C07K1/14(2006-01-01)

C07K14/745(2006-01-01)

(21) (22)

Application

2014123868/15, 2014-06-11

(24)

Start date

2014-06-11

(22)

Actual filing date

2014-06-11

(45)

Published

2016-05-10

(72)

Inventor

Berkovskij Aron LeonidovichSuvorov Aleksandr VladimirovichGolubev Evgenij MikhajlovichSergeeva Elena VladimirovnaDereza Tatjana LeonidovnaKutjurova Oksana GeorgievnaKhurdin Vjacheslav ViktorovichSlobodjan Anastasija Viktorovna

(73)

Holder

Federalnoe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Gematologicheskij Nauchnyj Tsentr Ministerstva Zdravookhranenija Rf

METHOD OF PRODUCING THROMBIN CONCENTRATE Russian patent published in 2016 - IPC A61K35/14 C12N9/74 C07K1/14 C07K14/745

Abstract RU 2583931 C2

FIELD: pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, specifically to a method of extracting a purified thrombin concentrate. Method for preparing thrombin concentrate, free from viruses comprising cryofractionation of fresh frozen human blood plasma, prothrombin complex separation on an anion exchange sorbent DEAE Sepharose Fast Flow, activation of prothrombin solution of CaCl₂ prothrombin complex composed of thrombin to yield viral inactivation by solvent-detergent and purified thrombin prepared cation exchange sorbent Fractogel EMD-SO₃ followed by sterile filtration and lyophilisation.

EFFECT: described method increases purity and output of end product.

1 cl, 1 tbl, 1 ex

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RU 2 583 931 C2

Authors

Berkovskij Aron Leonidovich

Suvorov Aleksandr Vladimirovich

Golubev Evgenij Mikhajlovich

Sergeeva Elena Vladimirovna

Dereza Tatjana Leonidovna

Kutjurova Oksana Georgievna

Khurdin Vjacheslav Viktorovich

Slobodjan Anastasija Viktorovna

Dates

2016-05-10—Published

2014-06-11—Filed